Evaluation of serum neopterin levels and its relationship with adipokines in pediatric obesity-related nonalcoholic fatty liver disease and healthy adolescents

ARSLAN N., Tokgoz Y., KÜME T., Bulbul M., SAYIN O., Harmanci D., ...More

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM, vol.26, pp.1141-1147, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26
  • Publication Date: 2013
  • Doi Number: 10.1515/jpem-2013-0029
  • Journal Name: JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1141-1147
  • Keywords: adipokine, adolescents, neopterin, non-alcoholic fatty liver disease, obesity, INTIMA-MEDIA THICKNESS, INSULIN-RESISTANCE, INFLAMMATORY MARKERS, METABOLIC SYNDROME, CAROTID-ARTERY, ATHEROSCLEROSIS, RISK, ASSOCIATION, CHILDREN, ACTIVATION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: Nonalcoholic fatty liver disease (NAFLD) is associated with inflammation and increased risk of atherosclerosis. Neopterin is regarded as a biochemical marker of cell-mediated immunity, which is secreted by monocytes and macrophages, mainly in response to interferon-gamma. The aim of the present study was to investigate the serum neopterin levels in obese adolescents and compare the neopterin levels in patients with and without NAFLD and also with healthy controls. The second aim of the study was to research the possible relationship between neopterin levels and adipokines (leptin, adiponectin, resistin, and ghrelin).