The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder

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de Zwarte S. M. C., Brouwer R. M., Agartz I., Alda M., Aleman A., Alpert K. I., ...Daha Fazla

BIOLOGICAL PSYCHIATRY, cilt.86, sa.7, ss.545-556, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 86 Sayı: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.biopsych.2019.03.985
  • Dergi Adı: BIOLOGICAL PSYCHIATRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.545-556
  • Anahtar Kelimeler: Bipolar disorder, Familial risk, Imaging, Meta-analysis, Neurodevelopment, Schizophrenia, GRAY-MATTER VOLUME, VOXEL-BASED MORPHOMETRY, HIGH GENETIC RISK, SOCIOECONOMIC-STATUS, SCHOOL PERFORMANCE, TWINS DISCORDANT, PREMORBID IQ, METAANALYSIS, CHILDHOOD, PREDISPOSITION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.