Primary cardiac diffuse large B-cell lymphoma with concurrent high MYC and BCL2 expression in an immunocompetent Chinese elderly woman
CARDIOVASCULAR PATHOLOGY, vol.31, pp.54-56, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 31
- Publication Date: 2017
- Doi Number: 10.1016/j.carpath.2017.07.006
- Journal Name: CARDIOVASCULAR PATHOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.54-56
- Keywords: Cardiac lymphoma, Diffuse large B-cell lymphoma, Double-expressor lymphoma
- Dokuz Eylül University Affiliated: Yes
Abstract
Primary cardiac lymphoma is a rare type of extranodal lymphoma that involves only heart and/or pericardium. It is usually observed in immunodeficient people. However, immunocompetent patients may also suffer from this disease. Most primary cardiac lymphomas are of B-cell lineage, and they usually present as diffuse large B-cell lymphoma (DLBCL). Diffuse large B-cell lymphoma with concurrently high MYC and BCL2 expression, which is named as double-expressor lymphoma (DEL), is a rare subtype of DLBCL. Herewe report a rare case of a primary cardiac DEL in an immunocompetent 65-year old Chinese woman. Echocardiography and magnetic resonance imaging revealed a mass of 6.6 cmx5.6 cm in the right atrium. No tumor formations were observed in other organs. Histopathologic examination showed that the cardiac tumor was diffuse large B-cell lymphoma, nongerminal center B-cell type by Hans algorithm. The tumor cells showed high MYC and BCL2 protein expression by immunohistochemistry, with high proliferative index. (C) 2017 Elsevier Inc. All rights reserved.