Investigation of Plasmid-mediated High-level Aminoglycoside Resistance in Carbapenem-resistant Klebsiella pneumoniae Isolates

Yis R., Sari Kaygisiz A. N., Gulay Z.

FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI, cilt.25, sa.3, ss.423-432, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.5578/flora.69733
  • Dergi Adı: FLORA INFEKSIYON HASTALIKLARI VE KLINIK MIKROBIYOLOJI DERGISI
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.423-432
  • Anahtar Kelimeler: 16S ribosomal RNA methyltransferases, High-level aminoglycoside resistance, Klebsiella pneumoniae, armA, SPECTRUM-BETA-LACTAMASE, ACINETOBACTER-BAUMANNII, FALSE SUSCEPTIBILITY, VITEK 2, ENTEROBACTERIACEAE, AMIKACIN, PREVALENCE, GENTAMICIN, EMERGENCE, STRAINS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: Carbapenemase-producing Klebsiella pneumoniae has become a leading cause of nosocomial infections in recent years, and aminoglycoside antibiotics have gained importance in the treatment of these infections due to their broad antimicrobial spectra, rapid bactericidal effects, and synergistic interactions with other antimicrobials. However, the excessive use of aminoglycosides has led to resistance. The aim of this study was to investigate plasmid-mediated, high-level resistance to aminoglycosides associated with 16S ribosomal RNA methyltransferases (16S-RMTase) in carbapenem-resistant K. pneumoniae isolates.