New alterations at potentially regulated regions of the Glial Derived Neurotrophic Factor gene in bipolar disorder

Safari R., Tunca Z., Ozerdem A., Ceylan D., ERESEN YAZICIOĞLU Ç., Sakizli M.

JOURNAL OF AFFECTIVE DISORDERS, cilt.167, ss.244-250, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 167
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.jad.2014.06.002
  • Dergi Adı: JOURNAL OF AFFECTIVE DISORDERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus
  • Sayfa Sayıları: ss.244-250
  • Anahtar Kelimeler: GDNF, Bipolar disorder, SNP, COMORBIDITY SURVEY REPLICATION, GENDER-DIFFERENCES, MOOD DISORDERS, ONSET, AGE, GDNF, PREVALENCE, EXPRESSION, SEQUENCES, LIFETIME
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Introduction: Glial Derived Neurotrophic Factor (GDNF) plays an important role in the survival and differentiation of neurons. We examined 5'upstream and 3' untranslated region of the GDNF gene by PCR amplification and direct sequencing to explore the effect of alteration in the potentially regulated part of GDNF in bipolar disorder.