Evaluation of the Efficacy of SiIdenafil Citrate Following Severe Head Trauma in an Experimental Rat Model

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Kilicarslan B., Kilicarslan E., Kızmazoğlu C., Aydin H. E., Kaya İ., Erşen Danyeli A., ...More

TURKISH NEUROSURGERY, vol.30, no.4, pp.501-506, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 4
  • Publication Date: 2020
  • Doi Number: 10.5137/1019-5149.jtn.23864-18.3
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.501-506
  • Keywords: Sildenafil citrate, Mannitol, Severe head trauma, Rat, DIFFUSE BRAIN-INJURY, CEREBRAL VASOSPASM, FUNCTIONAL RECOVERY, CYCLIC-GMP, SILDENAFIL, TERM, INHIBITION, MANNITOL, HYPOPERFUSION, TADALAFIL
  • Dokuz Eylül University Affiliated: Yes

Abstract

AIM: To investigate the acute effects of sildenafil citrate in an experimental model of severe head trauma, and to compare it with the efficacy of mannitol, which is an osmotically active agent frequently used in clinical treatment of traumatic brain injury (TBI).