Sinomenine ameliorates the airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in a murine model of chronic asthma.


Isik S., Karaman M., Micili S., Caglayan-Sozmen S., BAĞRIYANIK H. A., Arikan-Ayyildiz Z., ...More

Allergologia et immunopathologia, vol.46, no.1, pp.67-75, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 1
  • Publication Date: 2018
  • Doi Number: 10.1016/j.aller.2017.05.004
  • Journal Name: Allergologia et immunopathologia
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.67-75
  • Keywords: Asthma, Airway remodelling, Angiogenesis, Apoptosis, Murine model, Sinomenine, Th2, MATRIX METALLOPROTEINASES, IN-VITRO, ACUTUM, PROLIFERATION, RATS, PHARMACOLOGY, INVOLVEMENT, EXPRESSION, DISEASES, INJURY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Sinomenine (SIN), an alkaloid isolated from the root of Sinomenium acutum which has a variety of pharmacological effects, including anti-inflammation, immunosuppression and anti-angiogenesis. The present study aimed to evaluate the effects of SIN on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma.