Beneficial effects of erythropoietin on airway histology in a murine model of chronic asthma


Karaman M., Firinci F., Kiray M., Tuncel T., BAĞRIYANIK H. A., Yilmaz O., ...More

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, vol.40, no.2, pp.75-80, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2012
  • Doi Number: 10.1016/j.aller.2011.02.010
  • Journal Name: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.75-80
  • Keywords: Chronic asthma, Erythropoietin, Mouse, Treatment, BASEMENT-MEMBRANE, KAPPA-B, APOPTOSIS, PROTECTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Erythropoietin (EPO) is originally defined as a haematopoietic growth factor, but also has anti-inflammatory effects through cytokine modulation. This anti-inflammatory and cytokine modulating effect has not been investigated for the treatment of asthma. We aimed to determine the beneficial effects of erythropoietin on lung histology of murine model of chronic asthma.