Beneficial effects of erythropoietin on airway histology in a murine model of chronic asthma

Karaman M., Firinci F., Kiray M., Tuncel T., BAĞRIYANIK H. A., Yilmaz O., ...Daha Fazla

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.40, sa.2, ss.75-80, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 40 Sayı: 2
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1016/j.aller.2011.02.010
  • Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.75-80
  • Anahtar Kelimeler: Chronic asthma, Erythropoietin, Mouse, Treatment, BASEMENT-MEMBRANE, KAPPA-B, APOPTOSIS, PROTECTS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Erythropoietin (EPO) is originally defined as a haematopoietic growth factor, but also has anti-inflammatory effects through cytokine modulation. This anti-inflammatory and cytokine modulating effect has not been investigated for the treatment of asthma. We aimed to determine the beneficial effects of erythropoietin on lung histology of murine model of chronic asthma.