The effects of resveratrol on chronic constriction injury of sciatic nerve in rats.

BAĞRIYANIK H. A., Ersoy N., Cetinkaya C., Ikizoglu E., Kutri D., Ozcana T., ...More

Neuroscience letters, vol.561, pp.123-7, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 561
  • Publication Date: 2014
  • Doi Number: 10.1016/j.neulet.2013.12.056
  • Journal Name: Neuroscience letters
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.123-7
  • Keywords: Resveratrol, Chronic constriction injury, Locomotor function, Morphometry, Insulin-like growth factor 1, Rat sciatic nerve, PERIPHERAL NEUROPATHY, BRAIN-INJURY, EXPRESSION, MODEL, PAIN, ANTIOXIDANT, EXTRACT, L.
  • Dokuz Eylül University Affiliated: Yes


The aim of this study was to investigate the effects of resveratrol (RVT) in chronic constriction injury (CCI) of sciatic nerve by behavioral, histomorphological and immunohistochemical evaluations in rats. In this study, male Wistar rats were divided into three groups: sham (n = 7), CCI+saline (n = 7) and CCI+RVT (n = 7). After inducing CCI, treatment with 10 mg/kg/day of RVT or saline for 14 days was given. Locomotor function was assessed with rota-rod and open field tests. Morphologic alterations of sciatic nerve were assessed histologically by light and electron microscopy. Immunohistochemistry for insulin-like growth factor-1 (IGF-1) were performed. RVT treatment prevented motor impairment and histomorphological alterations caused by chronic constriction injury of sciatic nerve. IGF-1 immunoreactivity was significantly higher in RVT treated group then CCI induced group and positive correlated with morphometric parameters. These results indicate that RVT may reduce CCI induced damage and this effect may be mediated through the restoration of IGF-1 immunoreactivity. Crown Copyright (C) 2013 Published by Elsevier Ireland Ltd. All rights reserved.