How Does Early and Late Reoxygenation Following Hypoxia Affect Human Umbilical Vascular Endothelial Cells in Respect to Oxidative Stress?

ALTUN Z. S., İŞLEKEL G. H., SAYIN O., YÜKSEL EĞRİLMEZ M., GENÇ Ş., Genc K., ...Daha Fazla

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.35, sa.3, ss.225-229, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 3
  • Basım Tarihi: 2010
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.225-229
  • Anahtar Kelimeler: Endothelial cells, hypoxia, early reoxygenation, late reoxygenation, oxidative stress, NITRIC-OXIDE SYNTHASE, GLUCOSE DEPRIVATION, HYPOXIA/REOXYGENATION, EXPRESSION, APOPTOSIS, PROTECTS, OXYGEN
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: Vascular damage induced by hypoxia or hypoxia-reoxygenation has a crucial role in various clinicopathological conditions such as myocardial infarction, renal and cerebral ischemia. Endothelial cells might have a barrier function to vascular damage triggered by diverse stimuli or might be involved in this process. The aim of this study was to evaluate the roles of nitric oxide (NO), nitrotyrosine, endothelial nitric oxide synthase (eNOS), superoxide dismutase (SOD) and malondialdehyde (MDA) in hypoxia and hypoxia-reoxygenation in human vascular endothelial cells in-vitro.