The effects of levosimendan and dobutamine in experimental bupivacaine-induced cardiotoxicity.

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Kandemir U., MALTEPE F., Ugurlu B., Gokmen N., ÇELİK A.

BMC anesthesiology, cilt.13, sa.1, ss.28, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1186/1471-2253-13-28
  • Dergi Adı: BMC anesthesiology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.28
  • Anahtar Kelimeler: Bupivacaine, Cardiotoxicity, Levosimendan, Dobutamine, Rat, DECOMPENSATED HEART-FAILURE, SYSTEMIC TOXICITY, CARDIAC-SURGERY, RAT MODEL, RESUSCITATION, ROPIVACAINE, EPINEPHRINE, COMBINATION, SAFETY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Accidental intravenous exposure to bupivacaine is highly cardiotoxic and may lead to death. Positive inotropic agents are usually utilized in resuscitative efforts. We have compared the efficacy of levosimendan, a novel inotropic agent, with dobutamine and their combination in a rat model of bupivacaine intoxication.