The effects of levosimendan and dobutamine in experimental bupivacaine-induced cardiotoxicity.


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Kandemir U., MALTEPE F., Ugurlu B., Gokmen N., ÇELİK A.

BMC anesthesiology, vol.13, no.1, pp.28, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 1
  • Publication Date: 2013
  • Doi Number: 10.1186/1471-2253-13-28
  • Journal Name: BMC anesthesiology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.28
  • Keywords: Bupivacaine, Cardiotoxicity, Levosimendan, Dobutamine, Rat, DECOMPENSATED HEART-FAILURE, SYSTEMIC TOXICITY, CARDIAC-SURGERY, RAT MODEL, RESUSCITATION, ROPIVACAINE, EPINEPHRINE, COMBINATION, SAFETY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: Accidental intravenous exposure to bupivacaine is highly cardiotoxic and may lead to death. Positive inotropic agents are usually utilized in resuscitative efforts. We have compared the efficacy of levosimendan, a novel inotropic agent, with dobutamine and their combination in a rat model of bupivacaine intoxication.