Recommendations for Hepatitis B Immunoglobulin and Antiviral Prophylaxis Against Hepatitis B Recurrence After Liver Transplantation


AKARSU M., ÖNEM S., TURAN İ., Adali G., Akdogan M., Akyildiz M., ...More

TURKISH JOURNAL OF GASTROENTEROLOGY, vol.32, no.9, pp.712-719, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 32 Issue: 9
  • Publication Date: 2021
  • Doi Number: 10.5152/tjg.2021.21608
  • Journal Name: TURKISH JOURNAL OF GASTROENTEROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Page Numbers: pp.712-719
  • Keywords: Hepatitis B, liver transplantation, recurrence, VIRUS RECURRENCE, IMMUNE GLOBULIN, SURFACE-ANTIGEN, NUCLEOS(T)IDE ANALOGS, VIRAL-HEPATITIS, PREVENTION, MANAGEMENT, LAMIVUDINE, EFFICACY, OUTCOMES
  • Dokuz Eylül University Affiliated: Yes

Abstract

The combination of hepatitis B immunoglobulin and potent nucleos(t)ide analogs after liver transplantation is considered as the standard of care for prophylaxis against hepatitis B virus recurrence. However, the recommended doses, route of administration, and duration of HBIG administration remain unclear. Moreover, hepatitis B immunoglobulin-free prophylaxis with potent nucleos(t)ide analogs has shown promising disease outcomes in preventing hepatitis B virus recurrence. The current recommendations, produced by the Turkish Association for the Study of the Liver, Acute Liver Failure and Liver Transplantation Special Interest Group, suggest a reduced need for hepatitis B immunoglobulin administration with effective long-term suppression of hepatitis B virus replication using potent nucleos(t)ide analogs after liver transplantation.