Repair of calvarial defects in rats by prefabricated, degradable, long fibre composite implants

Scotchford C. A., Shataheri M., Chen P. -., Evans M., Parsons A. J., Aitchison G. A., ...Daha Fazla

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, cilt.96A, sa.1, ss.230-238, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96A Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/jbm.a.32977
  • Dergi Adı: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.230-238
  • Anahtar Kelimeler: degradable composite, bone repair, polycaprolactone, phosphate glass fibre, in vivo study, INION BIODEGRADABLE PLATES, BONE, RESPONSES, FIXATION, SURGERY, POLYCAPROLACTONE, POLYMERIZATION, 1ST-CENTURY, FRACTURES, PHOSPHATE
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

We report results from an initial small animal study designed to provide information on the biocompatibility of a novel biodegradable composite designed for craniomaxillofacial reconstruction. Rat calvarium was chosen as a clinically analogous model, which allowed comparison between experimental groups (PCL alone, PCL/phosphate glass, or PCL/bioglass implants) and control groups (empty defects or bone grafted defects). All animals recovered well from surgery and no clinical complications were observed. Histological assessment indicated a lack of inflammatory response. The amount of new bone formation at the dural aspect of the implant was statistically significantly higher in the PCL/phosphate glass group than the other experimental groups. This study confirms, in a clinically analogous model, the promise of the novel PCL/phosphate glass composite material. Work is planned toward manufacturing scale up and clinical trials. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 96A: 230-238, 2011.