Inhibition of Cancer Stem-Like Phenotype by Curcumin and Deguelin in CAL-62 Anaplastic Thyroid Cancer Cells

Koçdor M. A., Cengiz H., Ateş H., Koçdor H.

ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, cilt.19, sa.15, ss.1887-1898, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 15
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1871520619666191004144025
  • Dergi Adı: ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1887-1898
  • Anahtar Kelimeler: Anaplastic thyroid cancer, deguelin, curcumin, docetaxel, cancer stem cell, CSC phenotype, EPITHELIAL-MESENCHYMAL TRANSITION, CARCINOMA, CAPACITY, METASTASIS, MANAGEMENT, APOPTOSIS, MIGRATION, CULTURE, MARKERS, CYCLE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Anaplastic Thyroid Cancer (ATC) is one of the most lethal and aggressive human malignancies. Studies have shown that Cancer Stem-Cell (CSC) phenotype is mainly responsible for ATC aggressiveness. Cytostatic compounds are mostly ineffective because of multidrug resistance mechanisms driven by the CSC phenotype. Taxanes have limited efficacy. Recently, CSC inhibition using plant-derived, less toxic compounds, which have anti-cancer efficacy, has become a novel treatment modality. The aim of the study was to evaluate the anti-cancer activity of two natural compounds (curcumin and deguelin) on ATC cells and their CSC properties. In addition, the efficacies of these compounds were compared with that of docetaxel.