Formulation of low intensity direct current effects on wound healing of skin using genetic programming

Canseven A. G., Tohumoglu G., Cevik A., Seyhan N.

15th International Conference on Digital Signal Processing, Cardiff, United Kingdom, 1 - 04 July 2007, pp.507-508 identifier

  • Publication Type: Conference Paper / Full Text
  • Doi Number: 10.1109/icdsp.2007.4288630
  • City: Cardiff
  • Country: United Kingdom
  • Page Numbers: pp.507-508
  • Keywords: genetic programming, wound healing, hydroxyproline, electric stimulation, ELECTRICAL-STIMULATION
  • Dokuz Eylül University Affiliated: No


This study has two main purposes: Firstly.. the effect of electrical stimulation was studied on experimental wound healing of skin. It investigates whether a triggering was possible on collagen synthesis in wound healing before the 3rd day Of wounding, via measurements of hydroxyproline, a measure of collagen concentration in the wound tissue. Wound tissue hydroxyproline contents were determined with the effects of two different electric current intensities of. 200 mu A and 400 mu A at 48 and 72 hours after wounding by Woessner's Method. For both of the current intensities, statistically significant increases were found in hydroxyproline contents of current applied wounds with respect to their controls for 72 hours whereas decreased hydroxyproline content was found for 400 mu A of current intensities at 48 hours. Secondly, it was aimed to model and formulate how electric current effects wound healing using Genetic Programming (GP) based on experimental results. The accuracy of the proposed GP formulation is defined quantiatively by standard deviation (SD=0.39) and correlation coefficient (R=0.85), which is found to be high.