Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.

Isik, S.; Karaman, M.; Micili, SERAP; Caglayan-Sozmen, S.; BAĞRIYANIK, HÜSNÜ; Arikan-Ayyildiz, Z.; Uzuner, N.; Karaman, O.

doi:10.1016/j.aller.2016.12.003

Beneficial effects of ursodeoxycholic acid via inhibition of airway remodelling, apoptosis of airway epithelial cells, and Th2 immune response in murine model of chronic asthma.

Atıf İçin Kopyala

Isik S., Karaman M., Micili S., Caglayan-Sozmen S., BAĞRIYANIK H. A., Arikan-Ayyildiz Z., ...Daha Fazla

Allergologia et immunopathologia, cilt.45, sa.4, ss.339-349, 2017 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 45 Sayı: 4
Basım Tarihi: 2017
Doi Numarası: 10.1016/j.aller.2016.12.003
Dergi Adı: Allergologia et immunopathologia
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.339-349
Anahtar Kelimeler: Asthma, Airway remodelling, Apoptosis, Ursodeoxycholic acid, Murine model, Th2, PRIMARY BILIARY-CIRRHOSIS, CHENODEOXYCHOLIC ACID, INFLAMMATION, EXPRESSION, EFFICACY, TRIAL, MECHANISMS, GALLSTONES, DISEASES, INJURY
Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background and aims: In previous studies, anti-inflammatory, anti-apoptotic and immunomodulatory effects of ursodeoxycholic acid (UDCA) on liver diseases have been shown. In this study, we aimed to investigate the effects of UDCA on airway remodelling, epithelial apoptosis, and T Helper (Th)-2 derived cytokine levels in a murine model of chronic asthma.