Design and in vitro, in vivo evaluation of antioxidant bioadhesive gelsfor burn treatment


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GÖKÇE G., KARAVANA S. Y., BAĞRIYANIK H. A., PEKÇETİN Ç., ALĞIN YAPAR E., AYBAR TURAL G., ...More

TURKISH JOURNAL OF BIOLOGY, vol.46, no.3, pp.251-262, 2022 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 46 Issue: 3
  • Publication Date: 2022
  • Doi Number: 10.55730/1300-0152.2612
  • Journal Name: TURKISH JOURNAL OF BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.251-262
  • Keywords: Taurine, antioxidant, bio-adhesive gel, burn wound model, MUCOADHESIVE, TAURINE, MELATONIN, CHITOSAN
  • Dokuz Eylül University Affiliated: Yes

Abstract

Burn wounds are frequently encountered health problems, which need a new treatment approach especially in terms of good patient compliance. Availability of use of antioxidant agents and bio-adhesive gels in tissue healing can be an alternative as a new approach for wound healing. Antioxidant taurine containing bio-adhesive gels were prepared by using carbopol (CP) 940 and 934. Rheological and texture analyses were carried out on bio-adhesive gels for in vitro characterization. Wound model on Wistar rats was used to evaluate the in vivo evaluation of gels. Rheological and texture analyses showed that a carbopol bioadhesive gel has acceptable topically use dosage characteristics and in combination with Taurine it presented a successful wound healing effect via antioxidant parameters. In conclusion, bio-adhesive CP 940 (2%) gel containing 50 mM taurine could be promising in the treatment of burns by oxidative stress.