Effects of CO2 pneumoperitoneum on nephrotoxicity of sevoflurane: An experimental study in rabbits


Bayar M. S., Kuecuekgueclue S., Gokmen N., Dursun Z., Tuna E. B., Erkan N.

CHIRURGISCHE GASTROENTEROLOGIE, vol.22, no.2, pp.79-84, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 2
  • Publication Date: 2006
  • Doi Number: 10.1159/000092731
  • Journal Name: CHIRURGISCHE GASTROENTEROLOGIE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Page Numbers: pp.79-84
  • Keywords: laparoscopic surgery, pneumoperitoneum, sevoflurane, rabbit, PLASMA INORGANIC FLUORIDE, LOW-FLOW SEVOFLURANE, RENAL-FUNCTION, INVASIVE SURGERY, ANESTHESIA, ISOFLURANE, MARKERS, INHALATION, INDUCTION, HUMANS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: The purpose of this study is to evaluate the nephrotoxicity of sevoflurane inhalation anesthesia applied during carbon dioxide pneumoperitoneum ( CO2-PNP) which is conducted for a laparoscopic surgery treatment. Materials and Methods: 14 New Zealand white rabbits were used in this study. Initially, anesthesia was induced using 3.7% concentrated sevoflurane + 50% O-2/N2O. Then, a tracheotomy was performed, and the rabbits were mechanically ventilated. The first group ( n = 7) was subjected to CO2-PNP for 90 min with a constant intraabdominal pressure of 12 mm Hg, the second ( control group) ( n = 7) was exempted. The serum inorganic fluoride ( IF-) concentration was measured. The rabbits were sacrificed after 72 h, and one kidney each was immediately extracted for histopathological examination. Results: Serum IF- concentrations were not different in both groups. Histopathologically, mild renal damage was found in one rabbit in each group. Conclusion: CO2-PNP did not have any additional effect on the nephrotoxicity of sevoflurane.