Effect of Tadalafil on Neointimal Hyperplasia in a Rabbit Carotid Artery Anastomosis Model


Creative Commons License

Guzeloglu M., Aykut K., Albayrak G., Atmaca S., Oktar S., BAĞRIYANIK H. A., ...Daha Fazla

ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY, cilt.19, sa.6, ss.468-474, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 6
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5761/atcs.oa.12.02017
  • Dergi Adı: ANNALS OF THORACIC AND CARDIOVASCULAR SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.468-474
  • Anahtar Kelimeler: Neointima, tadalafil, nitric oxide, cyclic guanosine monophosphate signaling, rabbit, SMOOTH-MUSCLE-CELLS, PHOSPHODIESTERASE-5 INHIBITION, PROTEIN-KINASE, GRAFT FAILURE, RAT MODEL, PROLIFERATION, INJURY, CGMP, ENDARTERECTOMY, DYSFUNCTION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: Intimal thickening, which results from the response to arterial damage caused by therapeutic interventions or other reasons, is usually called as neointima. Neointimal hyperplasia is a main step in the pathogenesis of late-term restenosis, which is developed after vascular interventions. Reduction in nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling plays a substantial role in the pathogenesis of neointima formation. Phosphodiesterase V is detected in the peripheral coronary and pulmonary vascular smooth muscle cells and in the cardiac tissue. Based on the effects of phosphodiesterase V inhibitors on vascular smooth muscle cells, in the present study, the effect of tadalafil, a new member of phosphodiesterase V inhibitors, on neointimal hyperplasia was investigated in the rabbit carotid artery anastomosis model.