Dexamethasone-loaded chitosan-based genipin-cross-linked hydrogel for prevention of cisplatin induced ototoxicity in Guinea pig model


Aslier N. G. Y., Altınışık Tağaç A., Mungan Durankaya S., Calisir M., Ersoy N., Kırkım G., ...More

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, vol.122, pp.60-69, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 122
  • Publication Date: 2019
  • Doi Number: 10.1016/j.ijporl.2019.04.003
  • Journal Name: INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.60-69
  • Keywords: Cisplatin, Dexamethasone, Genipin, Guinea pig, Hydrogel, Ototoxicity, INNER-EAR, INTRATYMPANIC DEXAMETHASONE, CORTICOSTEROID PHARMACOKINETICS, ALPHA-TOCOPHEROL, MENIERES-DISEASE, HEARING-LOSS, PROTECTION, RESVERATROL, CHILDREN, DELIVERY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Objectives: The aim of this study was to investigate the protective effects of a sustained release form of dexamethasone (dex) loaded chitosan-based genipin-cross-linked hydrogel (CBGCH) in a guinea pig model of cisplatin (CP) induced hearing loss.