Decrease in cell proliferation by an matrix metalloproteinase inhibitor, doxycycline, in a model of immune-complex nephritis

Saglam F., Celik A., Tayfur D., ÇAVDAR Z., YILMAZ O., SARIOĞLU S., ...Daha Fazla

NEPHROLOGY, cilt.15, sa.5, ss.560-567, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 5
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1111/j.1440-1797.2010.01289.x
  • Dergi Adı: NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.560-567
  • Anahtar Kelimeler: doxycycline, extracellular matrix, glomerulonephritis, immune complexes, matrix metalloproteinase, EXTRACELLULAR-MATRIX, ENHANCED EXPRESSION, TISSUE INHIBITORS, GLOMERULONEPHRITIS, NEPHROPATHY, MATRIX-METALLOPROTEINASE-9, TGF-BETA-1, RAT
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aim: Renal expression of matrix metalloproteinases (MMP) and tissue inhibitors of MMP (TIMP) contribute to the development of tubulointerstitial fibrosis characteristic of progressive forms of primary glomerulonephritis (GN). The aim of this study was to investigate the therapeutic effect of MMP inhibitor, doxycycline, administration in an experimental rat model of immune-complex nephritis (ICN).