Effects of Intraperitoneal Injection of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells on Bronchiolitis Obliterans in Mice Model

IŞIK S., UZUNER N., KARAMAN M., KARAMAN Ö., KİRAY M., KOZANOĞLU İ., ...Daha Fazla

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, cilt.16, sa.3, ss.205-218, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 3
  • Basım Tarihi: 2017
  • Dergi Adı: IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.205-218
  • Anahtar Kelimeler: Bronchiolitis obliterans, Intraperitoneal administration, Mesenchymal stem cells, Murine model, LUNG TRANSPLANTATION, GROWTH-FACTOR, PROGENITOR CELLS, STROMAL CELLS, UP-REGULATION, MURINE MODEL, INJURY, ENGRAFTMENT, CHILDREN, DISEASE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Bone marrow-derived mesenchymal stem cells (BMSCs) can ameliorate a variety of lung diseases such as asthma, lung fibrosis, and acute lung injury by its anti-inflammatory and immunmodulatory effects. In this study, we developed a mouse model of bronchiolitis obliterans (BO) and evaluated the effects of the intraperitoneal administration of BMSCs on lung histopathology and cytokine levels.