Effects of Intraperitoneal Injection of Allogeneic Bone Marrow-derived Mesenchymal Stem Cells on Bronchiolitis Obliterans in Mice Model


IŞIK S., UZUNER N., KARAMAN M., KARAMAN Ö., KİRAY M., KOZANOĞLU İ., ...More

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, vol.16, no.3, pp.205-218, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 3
  • Publication Date: 2017
  • Journal Name: IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.205-218
  • Keywords: Bronchiolitis obliterans, Intraperitoneal administration, Mesenchymal stem cells, Murine model, LUNG TRANSPLANTATION, GROWTH-FACTOR, PROGENITOR CELLS, STROMAL CELLS, UP-REGULATION, MURINE MODEL, INJURY, ENGRAFTMENT, CHILDREN, DISEASE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Bone marrow-derived mesenchymal stem cells (BMSCs) can ameliorate a variety of lung diseases such as asthma, lung fibrosis, and acute lung injury by its anti-inflammatory and immunmodulatory effects. In this study, we developed a mouse model of bronchiolitis obliterans (BO) and evaluated the effects of the intraperitoneal administration of BMSCs on lung histopathology and cytokine levels.