Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines


Mustufa M. A., Hashmi I. A., Manzoor S., Ahmed A., Ahmed V., Aslam A., ...Daha Fazla

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.27, sa.5, ss.1491-1496, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 5
  • Basım Tarihi: 2014
  • Dergi Adı: PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1491-1496
  • Anahtar Kelimeler: Oleanolic acid, amino acid, HCC cell lines, amides, Periploca aphylla, URSOLIC ACID, BETULINIC ACID, TRITERPENOIDS, CANCER, DERIVATIVES, PREVENTION, APOPTOSIS, OLEANANE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Oleanolic acid (3 beta-hydroxy-olean-12-en-28-oic acid; OA-01), a pentacyclic triterpene, exhibit a wide range of pharmacological ad biological activities. We have isolated oleanolic acid from methanolic extract of Perzploca aphylla, collected from surroundings of Karachi in the month of February. Furthermore, four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line. Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 (p<0.0001) and OA-06 (p<0.01) showed significantly increased /higher inhibition rates.