The effects of PPAR-gamma agonist pioglitazone on renal ischemia/reperfusion injury in rats

REEL B., Guzeloglu M., BAĞRIYANIK H. A., Atmaca S., Aykut K., Albayrak G., ...Daha Fazla

JOURNAL OF SURGICAL RESEARCH, cilt.182, sa.1, ss.176-184, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 182 Sayı: 1
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1016/j.jss.2012.08.020
  • Dergi Adı: JOURNAL OF SURGICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.176-184
  • Anahtar Kelimeler: Renal ischemia/reperfusion, PPAR-gamma agonist, MMP, Oxidative stress, Inflammation, ACTIVATED-RECEPTOR-GAMMA, ISCHEMIA-REPERFUSION INJURY, MATRIX METALLOPROTEINASES, ALPHA, REGULATOR, FAILURE, TARGETS, LIGAND, PROLIFERATION, INFLAMMATION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Acute renal failure due to renal ischemia/reperfusion (IR) injury is a significant clinical problem in cardiovascular surgery. Reactive oxygen species and inflammation play essential roles in the pathophysiology of IR injury. Matrix metalloproteinases (MMPs) are enzymes that play important roles in inflammation and mediate extracellular matrix degradation. It is known that peroxisome proliferatoreactivated receptor-gamma agonists have antiinflammatory and antioxidant effects. In the present study, we aimed to investigate the effects of pioglitazone, a synthetic peroxisome proliferatoreactivated receptor-gamma agonist, on MMPs and oxidative stress in a renal IR injury model in rats.