Tuberculosis risk in the biologic era: tuberculin skin test conversion rates in children with rheumatologic diseases


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ÖZLÜ C., TÜRKUÇAR S., KARAOĞLU ASRAK H., ADIGÜZEL DUNDAR H., ÜNSAL Ş. E., BELET N.

TURKISH JOURNAL OF PEDIATRICS, vol.63, no.6, pp.978-985, 2021 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.24953/turkjped.2021.06.005
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.978-985
  • Keywords: biological agents, tuberculosis, children, TNF-alpha inhibitors, tocilizumab, canakinumab, LATENT TUBERCULOSIS, SCREENING-TESTS, INFECTION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background. The widespread use of biological treatments has increased the frequency of opportunistic infections such as tuberculosis (TB). The primary objective of our study was to determine the rate of tuberculin skin test (TST) conversion during biological therapy. The secondary objective was to monitor the side effects related to isoniazid (INH) prophylaxis, in the selected subgroup.