Development of an in vitro Injury Model of Ischemia Reperfusion in Human Brain Microvascular Endothelial Cells and the Evaluation of Cell Injury


ARSLAN N., SAYIN O., ALTUN Z. S., ÇAVDAR Z., YÜKSEL EĞRİLMEZ M., YENER N., ...More

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.35, no.3, pp.195-202, 2010 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 3
  • Publication Date: 2010
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.195-202
  • Keywords: Oxygen glucose deprivation, human brain microvascular endothelial cells, reactive oxygen species, ischemia-reperfusion model, OXYGEN-GLUCOSE DEPRIVATION, HYPOXIA-REOXYGENATION, OXIDATIVE STRESS, EXPRESSION, APOPTOSIS, GENERATION, DAMAGE, DEATH, MECHANISMS, PROTECTS
  • Dokuz Eylül University Affiliated: Yes

Abstract

Aim: In the course of ischemia reperfusion, injury / functional deterioration of the endothelium contribute to tissue damaging process. Hypoxia-reoxygenation model has been used as in vitro model of ischemia reperfusion injury. Oxygen glucose deprivation model can be considered to mimic the in vivo conditions. This study aimed to develop an in vitro model of ischemia reperfusion injury in human brain micro vascular endothelial cells and to evaluate the cell injury caused.