Protective Effect of Acetyl-L-Carnitine Against Doxorubicin-induced Cardiotoxicity in Wistar Albino Rats


Dundar H. A., KİRAY M., KIR M., KOLATAN H. E., BAĞRIYANIK H. A., ALTUN Z. S., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.47, no.7, pp.506-514, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 47 Issue: 7
  • Publication Date: 2016
  • Doi Number: 10.1016/j.arcmed.2016.11.008
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.506-514
  • Keywords: Acetyl-L-carnitine, Apoptosis, Doxorubicin cardiotoxicity, Echocardiography, Ultrastructure, ALPHA-LIPOIC ACID, OXIDATIVE STRESS, DAMAGE, BRAIN, METABOLISM, MODULATION, ADRIAMYCIN, MECHANISMS, TOXICITY, EXPOSURE
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background and Aims. Anthracyclines are one of the most preferred agents in practical pediatric oncology despite their dose-dependent cardiotoxic effects. The aim of this study was to investigate whether or not acetyl-L-carnitine (ALCAR) has protective effects on doxorubicin (DOX)-induced cardiotoxicity.