The influence of intrathecally administered midazolam on the analgesic effects of intrathecally administered ropivacaine for thermally induced pain Termal aǧri model̇inde i̇ntratekal ropi̇vakai̇ni̇n analjeżik etki̇leri̇ne i̇ntratekal mi̇dazolamin etk̇iṡi

Balkaya H., KÜÇÜKGÜÇLÜ S., GÖKMEN A. N., YILMAZ O., BAĞRIYANIK H. A., Özay R., ...More

Anestezi Dergisi, vol.15, no.4, pp.228-234, 2007 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 15 Issue: 4
  • Publication Date: 2007
  • Journal Name: Anestezi Dergisi
  • Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.228-234
  • Keywords: Analgeska, Intrathecal, Midazolam, Ropivacaine
  • Dokuz Eylül University Affiliated: Yes


Objective: This study was aimed to investigate whether the addition of midazolam to the intrathecal administration of ropivacaine in rats affects analgesic activity or has a histopathological effect on the spinal cord. Methods: Group Sham: All surgical processes were carried out except catheter insertion; Group S: 10 μL of 0,9% saline was administered through the catheter; Group R: 10 μL ropivacaine including 50 μg was administered through the catheter; Group M: 10 μL midazolam including 20 μg was administered through the catheter; Group MR: 10 μL of midazolam and ropivacaine mixture (with 20 μg midazolam and 50 μg ropivacaine) was administered through the catheter. Tail-flick and rotarod tests were performed at 10, 20, 30, 45, 60, and 90 mins after drug injection. The cross-sections obtained from the spinal cords of the rats were histopathologically evaluated. Results: The tail flick test mean values in group R, group M and group MR were significantly longer than in group S (p<0.05). In the comparison of group R with groups M and MR, the mean values of group MR were found to be significantly long (p<0.05). The rotarod test mean values of group M and group MR were found to be significantly low (p<0.05). No statistical histopathologic significance was found in any of the groups (p>0.05). Conclusion: The analgesic property of ropivacaine when administered intrathecally was augmented by intrathecally administered midazolam without producing any histopathological neurotoxicity.