ENDOCRINE PRACTICE, cilt.30, sa.5, ss.1-8, 2024 (SCI-Expanded)
Objective: There has been increasing evidence that patients with adrenal incidentalomas (AIs) who have 1-mg dexamethasone suppression test (DST) cortisol levels >0.9 mg/dL may be exposed to the adverse consequences of hypercortisolaemia. We aim to evaluate whether there is a difference in Beck Depression Inventory-II (BDI-II) and quality of life (QoL) score in patients with AI based on the threshold of a DST cortisol level >0.9 mg/dL.
Methods: This case-control study included 42 nonfunctional adrenal incidentaloma (NFAI), 53 mild autonomic cortisol secretion (MACS) and 42 healthy controls (HCs). In addition, patients were categorized as 0.9 and >0.9 mg/dL according to their DST cortisol results.
Results: There was no difference in the QoL and BDI-II scores of MACS compared to NFAI. The BDI-II score was higher and QoL was lower in MACS and NFAI compared to HCs. The difference in QoL and BDI-II scores between MACS and NFAI remained insignificant when the DST cortisol levels threshold was graded upward (5.0 mg/dL). The prevalence of depression was higher in the AI >0.9 mg/dL group than the AI 0.9 mg/dL group (respectively, 16.7% and 55.8%, P 1⁄4 .003), BDI-II scores were higher in the AI >0.9 mg/dL group than in the AI 0.9 mg/dL group and HCs. The DST was an independent factor affecting the frequency of depression (odds ratio: 1.39, P 1⁄4 .037).
Conclusion: MACS and patients with NFAI had similar QoL and depression scores according to the 1.8 mg/dL and above, whereas, had lower QoL and higher depression scores according to the 0.9 mg/dL. © 2024 AACE. Published by Elsevier Inc. All rights are reserved, including those for text and data mining,
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