Akademik Veri Yönetim Sistemi
IZMIR DR BEHCET UZ COCUK HASTANESI DERGISI, cilt.8, sa.3, ss.211-216, 2018 (ESCI)
Objective: Cytomegalovirus (CMV) infection is the most frequently seen congenital infection. While it is seen in all age groups, it may have some severe negative impacts on the fetus when exposed during intrauterine life. In our study, we evaluated the patients with symptomatic cytomegalovirus infection. Methods: Admission files of 40 patients admitted at Dr. Behcet Uz Children's Hospital between December 2004 and December 2009 for a variety of reasons and diagnosed as CMV infection as a result of clinical and laboratory analyses were investigated retrospectively. Diagnosis of the patients thought to be CMV infection was made based on CMV IGM positivities, and if facilities permitted diagnosis of CMV infection was established with CV DNA-PCR and antigenemia tests. Results: Symptomatic CMV infection was diagnosed in a total of 40 patients. When diagnostic classification was performed, 40% of them had congenital CMV and 60% of them acquired CMV. The frequency of symptomatic congenital CMV infection at our hospital between 2004-2009 was identified as 0.1 percent. The most frequently detected physical findings were hepatosplenomegaly (40%) and jaundice (30%). When we investigated prognosis of cases with congenital CMV we found motor mental retardation in 37.5%, hearing impairment in 25%, epilepsy in 12.5% and growth retardation 12.5% of the patients. In cases with acquired CMV improvement rates in patients treated for hepatitis and pneumonia were 70% and 100% respectively. Conclusion: The frequency of CMV infection in our study shows similarity with other developing countries. Patients with primary and secondary immunodeficiencies and newborns must be carefully approached. We recommend ganciclovir treatment for the selected cases.