The relationship of carotid intima-media thickness with anthropometric and metabolic parameters in patients with classic congenital adrenal hyperplasia


ÜNVER TUHAN H., ÖZTÜRK ATASOY T., ÇATLI G., ACAR S., ABACI A., ÜÇÜNCÜ EGELİ T., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.51, sa.4, ss.1738-1746, 2021 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 4
  • Basım Tarihi: 2021
  • Doi Numarası: 10.3906/sag-2001-57
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.1738-1746
  • Anahtar Kelimeler: Congenital adrenal hyperplasia, carotid intima-media thickness, subclinical atherosclerosis, CARDIOVASCULAR RISK-FACTORS, BODY-MASS INDEX, STEROID 21-HYDROXYLASE DEFICIENCY, AMBULATORY BLOOD-PRESSURE, WAIST-CIRCUMFERENCE, CHILDREN, ADOLESCENTS, DISEASE, PROFILE, HEIGHT
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/aim: We aimed to determine the presence of subclinical atherosclerosis using carotid intima-media thickness (CIMT) and biochemical parameters in children and adolescents with congenital adrenal hyperplasia (CAH). Materials and methods: Thirty-four patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency on regular glucocorticoid treatment for >_3 years and 31 healthy subjects were included in the study. The patients were divided into two groups according to the degree of control of the clinic, laboratory, and radiological parameters as a) "uncontrolled" [n= 22; with increased height velocity (HV) standard deviation score (SDS) (>_2 SDS), advanced bone age, serum 17-OH progesterone <2.0 and >_10.0 ng/mL or androstenedione <0.3 and >_ 3.0 ng/mL] or b) "controlled" [n= 12; with HV SDS < 2, bone age (BA)/ chronologic age (CA) ratio < 1.2, serum 17-OH progesterone between 2 and 10 ng/mL and androstenedione between 0.3 and 3.0 ng/mL]. Ultrasonographic examination of carotid artery was performed by the same radiologist using a B-mode ultrasound system. Results: There was no significant difference between the CAH and control groups in terms of median (IQR) CIMT values [0.47 (0.05) mm and 0.47 (0.07) mm, respectively; p > 0.05]. When subgroup comparisons were done in terms of median (IQR) CIMT values, there was no significant difference among the controlled, uncontrolled, and healthy control groups [0.45 (0.03) mm, 0.47 (0.04) mm, 0.47 (0.07) mm, respectively; p> 0.05]. In addition, CIMT levels were similar according to sex and disease control status. Conclusion: In this study, the CIMT values of CAH cases were similar to those of healthy subjects.