1,25-Dihydroxyvitamin D3 Induces N-Myc Downstream Regulated Gene-2 Expression In Papillary Thyroid Carcinoma Cells

Sipahi M., Bartik D. K., Doruk M., BAYRAKTAR F., OKTAY G.

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.4, sa.2, ss.128-132, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30621/jbachs.2020.1012
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.128-132
  • Anahtar Kelimeler: 1,25-Dihydroxyvitamin D-3, thyroid cancer, papillary thyroid cancer, N-myc downstream regulated gene 2, VITAMIN-D-RECEPTOR, NDRG2 EXPRESSION, DOWN-REGULATION, CANCER CELLS, D-3, BETA, DIFFERENTIATION, PROGRESSION, INHIBITION, INDUCTION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose: In addition to its role in serum calcium homeostasis, the anti-tumor function of 1,25-dihydroxyvitamin D-3 (calcitriol) in cancer development is well established. N-myc Downstream Regulated Gene 2 which functions as a tumor suppressor gene has recently been shown to be downregulated in various cancer leading to increased tumor incidence, progression and metastasis. The goal of this study was to investigate the possible effects of calcitriol treatment on NDRG2 expression in BCPAP papillary thyroid carcinoma cells.