The effects of preoperative immunosuppressive therapy on ischemia and reperfusion (I/R) injury in healthy rats

Kilinc S., Tan S., KOLATAN H. E., Ruscuklu D., Satici E., Kemiksiz M., ...Daha Fazla

INTERNATIONAL UROLOGY AND NEPHROLOGY, cilt.46, sa.2, ss.389-393, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1007/s11255-013-0548-2
  • Dergi Adı: INTERNATIONAL UROLOGY AND NEPHROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.389-393
  • Anahtar Kelimeler: Ischemia-reperfusion injury, Toll-like receptors, Rat model, TLR, DELAYED GRAFT FUNCTION, TOLL-LIKE RECEPTOR-2, KIDNEY-TRANSPLANTATION, KAPPA-B, ISCHEMIA/REPERFUSION INJURY, MOUSE MACROPHAGES, SIGNALING PATHWAY, LIVER, REJECTION, SURVIVAL
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Purpose Warm-ischemia-induced injuries might be encountered during renal transplants from cadavers and healthy donors. Toll-like receptors (TLR) in ischemia-reperfusion (I/R) injury are one of the indicators of intracellular injury pathways. The intensity of ischemic injury is directly proportionate to high TLR levels. To minimize the I/R injury, we investigated TLR2 and TLR4 levels on rats, which were pretreated with tacrolimus (FK506) before I/R.