Anxiety Caused by Traumatic Brain Injury Correlates to Decreased Prefrontal Cortex VEGF Immunoreactivity and Neuron Density in Immature Rats


Creative Commons License

BAYKARA B., Cetin F., BAYKARA H. B., AKSU İ., DAYI A., KİRAY M., ...More

TURKISH NEUROSURGERY, vol.22, no.5, pp.604-610, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 5
  • Publication Date: 2012
  • Doi Number: 10.5137/1019-5149.jtn.5633-11.1
  • Journal Name: TURKISH NEUROSURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.604-610
  • Keywords: Traumatic brain injury, Immature rat, Anxiety, VEGF, Prefrontal cortex, INDUCED HIPPOCAMPAL DAMAGE, ADRENOCORTICAL-RESPONSE, CRANIOCEREBRAL TRAUMA, DOPAMINERGIC ACTIVITY, MATERNAL SEPARATION, STRESS, NEUROENDOCRINE, DYSFUNCTION, DEPRESSION, SEVERITY
  • Dokuz Eylül University Affiliated: Yes

Abstract

AIM: Traumatic brain injury (TBI) may cause neuropsychiatric disorders such as anxiety disorder which has negative effects on cognitive functions and behavior. The aim of this study is to investigate the effects of TBI on anxiety and vascular endothelial growth factor (VEGF) immunoreactivity on the prefrontal cortex of immature rats, which is one of the anxiety-related regions of the brain in 7-day-old immature rats subjected to contusion injury.