Anxiety Caused by Traumatic Brain Injury Correlates to Decreased Prefrontal Cortex VEGF Immunoreactivity and Neuron Density in Immature Rats

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BAYKARA B., Cetin F., BAYKARA H. B., AKSU İ., DAYI A., KİRAY M., ...Daha Fazla

TURKISH NEUROSURGERY, cilt.22, sa.5, ss.604-610, 2012 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 22 Sayı: 5
  • Basım Tarihi: 2012
  • Doi Numarası: 10.5137/1019-5149.jtn.5633-11.1
  • Dergi Adı: TURKISH NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.604-610
  • Anahtar Kelimeler: Traumatic brain injury, Immature rat, Anxiety, VEGF, Prefrontal cortex, INDUCED HIPPOCAMPAL DAMAGE, ADRENOCORTICAL-RESPONSE, CRANIOCEREBRAL TRAUMA, DOPAMINERGIC ACTIVITY, MATERNAL SEPARATION, STRESS, NEUROENDOCRINE, DYSFUNCTION, DEPRESSION, SEVERITY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

AIM: Traumatic brain injury (TBI) may cause neuropsychiatric disorders such as anxiety disorder which has negative effects on cognitive functions and behavior. The aim of this study is to investigate the effects of TBI on anxiety and vascular endothelial growth factor (VEGF) immunoreactivity on the prefrontal cortex of immature rats, which is one of the anxiety-related regions of the brain in 7-day-old immature rats subjected to contusion injury.