A case of severe thrombocytopenia developed due to cytomegalovirus and ganciclovir treatment in a healthy infant

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İNCE O. T., Celik Cengiz S., Kanik A., Sarioglu B.

Izmir Dr Behcet Uz Cocuk Hastanesi Dergisi, cilt.6, sa.3, ss.231-233, 2016 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 6 Sayı: 3
  • Basım Tarihi: 2016
  • Doi Numarası: 10.5222/buchd.2016.231
  • Dergi Adı: Izmir Dr Behcet Uz Cocuk Hastanesi Dergisi
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.231-233
  • Anahtar Kelimeler: Cytomegalovirus, healthy child, ganciclovir, thrombocytopenia, IMMUNOCOMPETENT PATIENTS, INFECTION
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Cytomegalovirus (CMV) infection is a common disease worldwide. While infection in immunocompetent individuals has traditionally been considered a benign and self-limited condition, a few studies have reported the clinical manifestations and treatment of CMV infection among immunocompetent patients. Ganciclovir treatment in children with cytomegalovirus infection is still controversial and it is used only in selected cases. We report here a case of a previously healthy 52-day-old girl who developed severe CMV disease with prolonged fever and profound thrombocytopenia. Short-term intravenous ganciclovir treatment was associated with immediate and sustained resolution of the symptoms as well as a sharp decrease of CMV viremia. Antiviral therapy should be considered in select cases of severe primary CMV infection in immunocompetent children.