Value of expression of insulin-like growth factor-1 receptor in gastric adenocarcinomas and normal gastric tissues.


Topalak O., Kantar F. U., Ulukus C., Kupelioglu A.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology, cilt.25, sa.2, ss.141-6, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2014
  • Doi Numarası: 10.5152/tjg.2014.4496
  • Dergi Adı: The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.141-6
  • Anahtar Kelimeler: Insulin-like growth factor-1 receptor, gastric cancer, metastasis, RENAL-CELL CARCINOMAS, IGF-I, DOWN-REGULATION, ANTISENSE RNA, MELANOMA-CELLS, BREAST-CANCER, COLON-CANCER, FACTOR-ALPHA, TRANSFORMATION, METASTASIS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background/Aims: Insulin-like growth factor-1 receptor (IGF-1R) plays critical roles in cell proliferation, differentiation, apoptosis, and transformation. Suppression of IGF-1R by means of antisense methods and specific antibodies causes cell apoptosis and growth inhibition of cancer cells. The present study aims to investigate whether there is a difference between normal and cancerous tissue with respect to IGF-1R expression and to assess the relationship between IGF-1R expression and tumor stage, degree of differentiation, and lymph node metastasis by examining IGF-1R expression in cancerous and normal tissues of gastric adenocarcinoma cases of different stages.