Effects of Curcumin on Lung Histopathology and Fungal Burden in a Mouse Model of Chronic Asthma and Oropharyngeal Candidiasis


KARAMAN M., Ayyildiz Z. A., Firinci F., KİRAY M., BAĞRIYANIK H. A., YILMAZ O., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.42, no.2, pp.79-87, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 42 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1016/j.arcmed.2011.01.011
  • Journal Name: ARCHIVES OF MEDICAL RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.79-87
  • Keywords: Chronic asthma, Mouse, Curcumin, Oropharyngeal candidiasis, C. albicans colonization, NITRIC-OXIDE, AIRWAY INFLAMMATION, MURINE MODEL, COMPLEMENTARY, INHIBITION, MEDICINE, EFFICACY
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background and Aims. Oropharyngeal candidiasis (OPC) is one of the most common local side effects of current therapy in chronic asthma. New therapeutic options with fewer side effects and reverse chronic changes are needed. Curcumin, as a promising antiinflammatory and antifungal agent, could be a candidate of alternative therapy in asthma. This study aimed to determine the efficacy of orally administrated curcumin on lung histopathology, serum nitric oxide levels and fungal burden in a murine model of asthma and OPC.