Effects of Curcumin on Lung Histopathology and Fungal Burden in a Mouse Model of Chronic Asthma and Oropharyngeal Candidiasis

KARAMAN M., Ayyildiz Z. A., Firinci F., KİRAY M., BAĞRIYANIK H. A., YILMAZ O., ...Daha Fazla

ARCHIVES OF MEDICAL RESEARCH, cilt.42, sa.2, ss.79-87, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.arcmed.2011.01.011
  • Dergi Adı: ARCHIVES OF MEDICAL RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.79-87
  • Anahtar Kelimeler: Chronic asthma, Mouse, Curcumin, Oropharyngeal candidiasis, C. albicans colonization, NITRIC-OXIDE, AIRWAY INFLAMMATION, MURINE MODEL, COMPLEMENTARY, INHIBITION, MEDICINE, EFFICACY
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background and Aims. Oropharyngeal candidiasis (OPC) is one of the most common local side effects of current therapy in chronic asthma. New therapeutic options with fewer side effects and reverse chronic changes are needed. Curcumin, as a promising antiinflammatory and antifungal agent, could be a candidate of alternative therapy in asthma. This study aimed to determine the efficacy of orally administrated curcumin on lung histopathology, serum nitric oxide levels and fungal burden in a murine model of asthma and OPC.