Comparison of TNF antagonism by etanercept and dexamethasone on airway epithelium and remodeling in an experimental model of asthma


YILMAZ Ö., KARAMAN M., BAĞRIYANIK H. A., Firinci F., KİRAY M., Turkeli A., ...More

INTERNATIONAL IMMUNOPHARMACOLOGY, vol.17, no.3, pp.768-773, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.1016/j.intimp.2013.08.021
  • Journal Name: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.768-773
  • Keywords: Mouse model of asthma, Remodeling, Inflammation, Tumor necrosis factor, Steroid, TUMOR-NECROSIS-FACTOR, SMOOTH-MUSCLE, FACTOR-ALPHA, ADHESION MOLECULES, BASEMENT-MEMBRANE, DOUBLE-BLIND, INFLAMMATION, MODULATION, ALLERGEN, EXPRESSION
  • Dokuz Eylül University Affiliated: Yes

Abstract

Background: The aim of the study was to compare the influence of TNF antagonism and corticosteroid treatment on epithelial, smooth muscle and basement membrane component of airway remodeling in an experimental murine model of chronic asthma.