61st Congress of ERA, Stockholm, İsveç, 23 - 26 Mayıs 2024, (Özet Bildiri)
Background and Aims: Valvular calcification is concordant with vascular calcification and develops faster in end-stage renal disease
patients than in the average population.There are contradictory reports aboutthe pathophysiology and the predictive value of valvular
calcification regarding mortality in this patient population. Aortic peak wave velocity (Vmax) measurement is a non-invasive and
reliable marker for the diagnosis of valve calcification. Our study analyzes cardiovascular risk prediction effect of increasing levels of
Vmax at different time points in peritoneal dialysis (PD) patients.
Method: We conducted a retrospective, single-center study of incident PD patients under follow-up between January 1992 and January
2023 in our clinic. Demographics, laboratory, and echocardiographic findings were obtained from medical records. Patients without a
baseline echocardiography were excluded. Vmax is defined as the last Vmax minus baseline Vmax levels. The patients were divided
into two subgroups: Vmax-stable and Vmax-increased.
Results: The baseline demographics, laboratory, and clinical characteristics, including daily elemental calcium and calcitriol usage,
were similar between Vmax-stable and Vmax-increased groups. Baseline calcium (Ca), phosphate (P), and annual CaXP levels were
significantly higher in Vmax-increased group [p = 0.01, p = 0.02, and (F(1,27) = 10.415, p = 0.003), respectively]. Cardiovascular mortality
was 9.8% in Vmax-stable group and 26.8% in Vmax-increased group (p = 0.02).
Conclusion: During a follow-up of 20 years, increasing Vmax values were associated with higher CaxP levels in PD patients. Increased
Vmax levels, along with higher CaxP levels, are associated with cardiovascular mortality. Even without clinical manifestations, Vmax
follow-up is a non-invasive, easily accessible method and might identify the high-risk group regarding cardiovascular mortality in the
PD population