Beneficial effects of arginase inhibition and inhaled L-arginine administration on airway histology in a murine model of chronic asthma

Arikan-Ayyildiz Z., Karaman M., Tuncel T., Kiray M., BAĞRIYANIK H. A., Yilmaz O., ...Daha Fazla

ALLERGOLOGIA ET IMMUNOPATHOLOGIA, cilt.42, sa.4, ss.316-323, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 42 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.aller.2013.01.001
  • Dergi Adı: ALLERGOLOGIA ET IMMUNOPATHOLOGIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.316-323
  • Anahtar Kelimeler: Asthma, Murine model, L-Arginine, Arginase inhibition, nor-NOHA, NITRIC-OXIDE SYNTHASE, INFLAMMATION, ALLERGEN, HYPERRESPONSIVENESS, SUPEROXIDE, DISEASE, MICE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Background: Increased arginase activity in the airways induces reduced bioavailability of L-arginine and cause deficiency of bronchodilatating and anti-inflammatory nitric oxide (NO). Therefore, arginine and arginase inhibitors may have therapeutic potential in the treatment of asthma. Using a murine model of asthma, we aimed to investigate the effects of inhaled L-arginine and arginase inhibitor N omega-hydroxy-nor-L-arginine (nor-NOHA) and co-treatment on airway histology of asthmatic lung tissue.