Effects of Inhaled L-Arginine Administration in A Murine Model of Acute Asthma

Arikan-Ayyildiz Z., KARAMAN M., Firinci F., KİRAY M., BAĞRIYANIK H. A., YILMAZ O., ...Daha Fazla

IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY, cilt.13, sa.5, ss.317-323, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 5
  • Basım Tarihi: 2014
  • Dergi Adı: IRANIAN JOURNAL OF ALLERGY ASTHMA AND IMMUNOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.317-323
  • Anahtar Kelimeler: Acute asthma, Inflammation, L-arginine, Murine model, SaO(2), NITRIC-OXIDE SYNTHASE, AIRWAY INFLAMMATION, ARGINASE, ALLERGEN, SUPEROXIDE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Increased arginase activity in the airways decreases L-arginine and causes deficiency of bronchodilating and anti-inflammatory nitric oxide (NO) in asthma. As, it is suggested that Larginine may have therapeutic potential in asthma treatment, we aimed to investigate the effects of inhaled L-arginine on oxygen saturation (SaO(2)) and airway histology in a murine model of acute asthma.