Molecular Characterization of Drug Resistance in Hepatitis B Viruses Isolated from Patients with Chronical Infection in Turkey

Asan A., SAYAN M., AKHAN S., Koruk S. T., AYGEN B., Sirmatel F., ...Daha Fazla

HEPATITIS MONTHLY, cilt.18, sa.1, 2018 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.5812/hepatmon.12472
  • Dergi Adı: HEPATITIS MONTHLY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: Hepatitis B Virus, Sequence Analysis, HBsAg, Antiviral Drug Resistance, Chronic Hepatitis B, HBV Polymerase, ESCAPE HBV MUTANTS, ANTIVIRAL THERAPY, NAIVE PATIENTS, NUCLEOS(T)IDE ANALOGS, CLINICAL-PRACTICE, CHINESE PATIENTS, POLYMERASE GENE, PUBLIC-HEALTH, C VIRUS, MUTATIONS
  • Dokuz Eylül Üniversitesi Adresli: Hayır

Özet

Background: Hepatitis B virus (HBV) has a high mutation rate due to its unusual replication strategy leading to the production of a large number of virions with single and double mutations. The mutations, in turn, are associated with the development of drug resistance to nucleos(t)ide analogs (NUCs) in patients before and during NUCs therapy.