Effect of Mesenchymal Stem Cells on Cochlear Cell Viability After Cisplatin Induced Ototoxicity

Erçetin A. P., Olgun Y., Aktaş S., Aydin M., Evin Eskicioğlu H., Altun Z. S., ...Daha Fazla

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.4, sa.3, ss.378-383, 2020 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 3
  • Basım Tarihi: 2020
  • Doi Numarası: 10.30621/jbachs.2020.1305
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.378-383
  • Anahtar Kelimeler: mesenchymal stem cells, cochlear cells, cisplatin ototoxicity, MECHANISMS
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Aims: Ototoxicity is one of the main side effects of the chemotherapeutic agent Cisplatin (CDDP). CDDP ototoxicity is caused by damage of the organ of Corti, spiral ganglion cells or lateral wall (stria vascularis and spiral ligament). Mesenchymal stem cells (MSCs) were shown to differentiate into neurogenic and auditory hair cells in vitro. In this study, effect of MSCs in CDDP ototoxicity model of HEI-OC1 cochlear cells was evaluated.