Effects of pressure- and volume-controlled inverse ratio ventilation on haemodynamic variables, intracranial pressure and cerebral perfusion pressure in rabbits: a model of subarachnoid haemorrhage under isoflurane anaesthesia

Taplu A., Gokmen N., Erbayraktar S., Sade B., Erkan N., Karadibak K., ...More

EUROPEAN JOURNAL OF ANAESTHESIOLOGY, vol.20, no.9, pp.690-696, 2003 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 20 Issue: 9
  • Publication Date: 2003
  • Doi Number: 10.1097/00003643-200309000-00003
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.690-696
  • Keywords: nervous system physiology, cerebrospinal fluid pressure, intracranial pressure, rabbits, respiration, artificial, intermittent positive-pressure ventilation, positive-pressure respiration, SEVERE RESPIRATORY-FAILURE, LUNG INJURY, BLOOD-FLOW, I/E RATIOS, HALOTHANE, VASOSPASM
  • Dokuz Eylül University Affiliated: Yes


Background and objective: An inverse I:E ratio (inspiratory time > expiratory time) may have benefits in patients suffering trauma who requiring lung ventilation. However, this application may be deleterious if there is concomitant head injury. We aimed to determine the physiological effects of pressure- and volume-controlled modes of inverse ratio (I:E = 2:1) ventilation of the lungs, while maintaining normocapnia, in a rabbit model of raised intracranial pressure (ICP).