Rat models of colistin nephrotoxicity: previous experimental researches and future perspectives

Heybeli C., Oktan M. A., ÇAVDAR Z.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, cilt.38, sa.8, ss.1387-1393, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 38 Sayı: 8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1007/s10096-019-03546-7
  • Dergi Adı: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1387-1393
  • Anahtar Kelimeler: Animal model, Colistin, Nephrotoxicity, INTRAVENOUS COLISTIN, COLISTIMETHATE, MITOCHONDRIAL, NEPHROPATHY, ACTIVATION, UNITS, DRUG, MICE
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Colistin is an old antibiotic, which is abandoned decades ago because of high nephrotoxicity rates. However, it is reintroduced to clinical medicine due to lack of newly discovered antibiotics and is still widely used for the treatment of resistant gram-negative infections. Discovering mechanisms to reduce nephrotoxicity risk is of significant importance since exposed patients may have many other factors that alter kidney functions. Several agents were evaluated in animal models of colistin nephrotoxicity as a means to prevent kidney injury. Considerable heterogeneity exists in terms of reporting colistin dosing and experimental designs. This issue leads clinicians to face difficulties in designing studies and sometimes may lead to report dosing strategies inadequately. Here, we present a review according to animal models of colistin nephrotoxicity using data gathered from previous experiments to draw attention on possible complexities that researchers may encounter.