Does peri-implant bone loss affect the LL-37 and proteinase 3 levels in peri-implant sulcus fluid?


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Turkoglu O., EFEOĞLU C., Atmaca H.

INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY, vol.6, no.1, 2020 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 6 Issue: 1
  • Publication Date: 2020
  • Doi Number: 10.1186/s40729-020-00240-8
  • Journal Name: INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED)
  • Keywords: Cathelicidin LL-37, Peri-implantitis, Peri-implant sulcus fluid, Proteinase 3, GINGIVAL CREVICULAR FLUID, ANTIMICROBIAL PEPTIDES, CATHELICIDIN LL-37, BIOMARKER LEVELS, NATURAL TEETH, EXPRESSION, INTERLEUKIN-8, OSTEOCALCIN, PREVALENCE, ELASTASE
  • Dokuz Eylül University Affiliated: No

Abstract

Background Inactive human cathelicidin antimicrobial peptide is present in neutrophils, and proteinase 3 activates this peptide by producing active LL-37 peptide. LL-37 acts as a defensive peptide in the oral tissues. In the present study, the aim was to evaluate LL-37 and proteinase 3 levels in peri-implant sulcus fluid (PISF) in implants with and without peri-implantitis. Methods Patients who simultaneously had dental implants with peri-implantitis and without peri-implantitis were included in the study. Forty-four samples with peri-implantitis and 34 samples without peri-implantitis from 16 patients were obtained. Intraoral evaluations such as pocket depth, modified sulcus bleeding index, and modified plaque index were noted. Enzyme-linked immunosorbent assay was used for the evaluation of PISF LL-37 and proteinase 3 levels. Results PISF volume was significantly increased in the implants with peri-implantitis than those without peri-implantitis (p< 0.05). No difference was present between PISF LL-37 and proteinase 3 total amounts between the implants with and without peri-implantitis (p> 0.05). Pocket depths and PISF LL-37 and proteinase 3 levels were not correlated in the groups (p> 0.05). Conclusions PISF volume might be increased in response to peri-implant bone destruction. However, peri-implant tissue destruction caused by peri-implantitis does not seem to affect PISF LL-37 and proteinase 3 levels.