Limitations of Cross-Talk Between Osteosarcoma and Bone Marrow-Derived Mesenchymal Stem Cells

Başbınar Y., Uysal T., Karaca C., Daskin E., Meco H. E., Pakdemirli A., ...Daha Fazla

JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES, cilt.3, sa.2, ss.83-88, 2019 (ESCI) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 3 Sayı: 2
  • Basım Tarihi: 2019
  • Doi Numarası: 10.30621/jbachs.2019.611
  • Dergi Adı: JOURNAL OF BASIC AND CLINICAL HEALTH SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.83-88
  • Anahtar Kelimeler: Osteosarcoma, MG-63, BM-MSCs, Metastasis, Cross-Talk, BREAST-CANCER CELLS, N-CADHERIN, METASTASIS, GROWTH, BIOGENESIS, EXOSOMES
  • Dokuz Eylül Üniversitesi Adresli: Evet

Özet

Objectives: Metastasis is a multi-step process which leads the tumor cells to escape from primer tumor region due to their need to gain malign phenotypes. While the effect of bone marrow-derived mesenchymal stem cells upon metastasis is not certain, some studies point out bone marrow-derived mesenchymal stem cells (BM-MSCs) to have this ability due to cell-cell interaction, released cytokines, and organization with the extracellular matrix in the micro-environment. Cross-talk via soluble factors also shifts the metastatic character.