Akademik Veri Yönetim Sistemi
Özdemir E.(Yürütücü), Altun Z. S., Kılıç Özdemir S., Aktaş S., Barış M. M., Yılmaz O., et al.
TÜBİTAK Projesi, 2021 - 2024
Breast cancer is the most widely seen cancer type in women. Extrusion of tumor is mainly applied by surgery
in breast cancer theraphy and afterwards chemotheraphy and radiotherapy were applied depending on the stages level.
The most widely used chemotherapy method is Doxorubicine (DOX) which is in the anthracyclic family. However, the
use of DOX is limited due to side effects such as cardiotoxic, nefrotoxic, heheotoxlogic etc.. Also, what is important is
that some of the anti cancer drug was pumped back to the out of the cell due to multi durug resistance, which reduces
the effectiveness of chemotheraphy to an important level, resulting in recurrency of the cancer, metasthasis, and death
results in patients. In the proposed project,it wasaimed to develop a method on effective drug delivery amd reversing
the multidrug resistance in the breast cancer issue.
In the proposed method, the production, in-vitro and in-vivo effectiveness of the liposomes, containing
Tariquidar (TRQ) which decreases the multi drug resistance, loaded with DOX as an anti cancer drug, and targeted with
Fucoidan (FUC) covered the surface, will be investigated. An effective drug delivery will be achieved in the tumor site by
pumping of liposomes into the tumor region with ossilation of contrast agent microbubbles under ultrasound, increasing
the specific binding of those liposomes to the cancer cells, and separately, by creation of pores on the cell membranes
by sonoporation during the bursting of microbubbles under high power ultrasound. It was expected that the multi
functional delivery system designed in the project will increase the chance of success in the cancer treatment when
applied with the ultrasound contrast agent microbubbles.
Interdisciplinary colleborations are required from the development of the multi fuctional nano delivery wheicles to in-vitro
verification in lab condition, to show in-vivo effectiveness in animal model and up to the use in the treatment through all
the stages. The project will be implemented by a strong team gathered from academicians in the Izmir Institute of
Technology (IZTECH) and Dokuz Eylul University (DEU) with a diverse area of expertise in Chemical Engineeing,
Biochemical Engineering, Cell Biology, Clinical Biochemistry, Patalogy, Oncology, Test Animals, and Radiology. Five
Graduate students will be employed in the project.
The information and experince gathered at the end of the project will make significant progress in the area of
cancer tratment. There will be acheived a new method in cancer treatment with development of the proposed multi
fuctional targeted drug delivery and release system. This will add our nations to move to a level to be able to produce its
own drug/drug delivery system, as mentioned in the 11th development plan as the medicine-medical equipment sector
in the priority sectors.