Creative Commons License

Yahşi Y., Köse M. D., Bayraktar O.

4th International Conference on Natural and Engineering Sciences, Muğla, Turkey, 09 October 2018

  • Publication Type: Conference Paper / Full Text
  • City: Muğla
  • Country: Turkey
  • Dokuz Eylül University Affiliated: No


The beneficial effects of trans-resveratrol on health are widely accepted. However, when exposed to heat and UV light, the

degradation of trans-resveratrol to less active form cis-resveratrol limits its use in industrial applications. Due to this reason, it is

crucial to preserve the stability of trans-resveratrol by using carrier systems. This study aimed to encapsulate the trans-resveratrol

in core/shell nanoparticles composed of eggshell membrane proteins and silk fibroin, respectively, using a coaxial

electrospraying technique to preserve its stability. The size of the nanoparticles ranged from 8.2 to 254 nm. Keeping the

encapsulation yield at the maximum level (96.9%), electroencapsulation process parameters which minimize the average particle

diameter (23.8 nm) were found to be A (silk fibroin concentration) = 30.7 mg/ml, B (ratio of flow rates) = 0.72, C (applied

voltage) = 18.8 kV, and D (distance) = 12.2 cm. Encapsulation efficiency varied between 40.05 and 96.41%. Detection of

antioxidant capacity of released trans-resveratrol suggested that nanoparticles could be a suitable delivery system for sustained

release of trans-resveratrol with preserved thermal and UV photostability. Central composite design (CCD) and the response

surface methodology (RSM) were successfully used to optimize the electroencapsulation process parameters for the preparation

of trans-resveratrol loaded core/shell nanoparticles. It was found that these parameters seemed to be varied depending on the

response required. Therefore, an optimum process should be investigated to obtain desired responses such as high encapsulation

yield, high encapsulation efficiency, and small average particle size while preserving the thermal and UV stabilities at reasonable