Lithium-induced alterations in nucleoside triphosphate levels in human brain: a proton-decoupled (31)p magnetic resonance spectroscopy study

Yildiz A., Moore C., Sachs G., Demopulos C., Tunca Z., Erbayraktar Z., ...More

PSYCHIATRY RESEARCH-NEUROIMAGING, vol.138, no.1, pp.51-59, 2005 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 138 Issue: 1
  • Publication Date: 2005
  • Doi Number: 10.1016/j.pscychresns.2003.10.005
  • Journal Name: PSYCHIATRY RESEARCH-NEUROIMAGING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.51-59
  • Keywords: lithium, proton-decoupled (31)p MRS, nucleoside triphosphates, SIGNAL-TRANSDUCTION PATHWAYS, MOOD-STABILIZING AGENTS, BIPOLAR DISORDER, IN-VIVO, ADENYLATE-CYCLASE, MITOCHONDRIAL-DNA, GENE-EXPRESSION, CEREBRAL-CORTEX, METABOLISM, BCL-2
  • Dokuz Eylül University Affiliated: No

Abstract

We examined how lithium ' s demonstrated effects on various cellular processes in human brain would be reflected in the P-31 magnetic resonance spectra of living human beings with respect to brain high-energy phosphate metabolites. Eight healthy volunteers received a baseline P-31 magnetic resonance spectroscopy (MRS) scan, after which they received lithium carbonate, 900 mg/day, for 14 days. Follow-up MRS scans were obtained on day 7 and on day 14. We detected a lithium-incluced decrease in alpha-, beta-, gamma- and total nucleoside triphosphate NTP levels with chronic administration of lithium. On day 7, significant decreases were noted in gamma-NTP (14%) and total NTP (11%) levels. There was a trend for a decrease in beta-NTP (11%) levels. On day 14, significant decreases were noted in alpha-NTP (7%) and total NTP (8%) levels. There was a trend for a decrease in beta-NTP (16%) levels. Lithium caused a 25% reduction in inorganic phosphate (Pi) levels on day 14. The theoretical relevance of the lithium-induced alterations on brain high-energy phosphates to the lithium-induced modifications of neuroplasticity is discussed. (c) 2004 Elsevier Ireland Ltd. All rights reserved.